【摘要】 腺苷A2A受体在基底神经节选择性表达并与运动行为有关。流行病学研究和实验室研究均表明阻断腺苷A2A受体能减轻多巴胺能神经元的退行性病变。腺苷A2A受体拮抗剂在改善PD症状的同时还能减缓疾病的进程。因此,腺苷A2A受体拮抗剂很可能成为治疗PD的新药物。更多还原

【Abstract】 Adenosine A_ 2A receptors are selectively localized in basal ganglia and can affect the locomotor activity. Epidemiological and laboratory data have suggested that A_ 2A blockade may confer neuroprotection against the underlying dopaminergic neuron degeneration. A_ 2A receptor antagonist may ameliorate the symptom of Parkinsons disease (PD) and block the disease progress. Thus, the data suggested that A_ 2A receptor antagonist might be effective as a novel therapy for the management of PD.更多还原