【摘要】 目的探讨斑状角膜营养不良患者的临床特征、诊断及手术治疗。设计回顾性病例系列。研究对象18例(36眼)斑状角膜营养不良患者。方法分析患者临床资料,包括病史、视力、裂隙灯显微镜检查以及手术治疗方法和术后随访结果。主要指标角膜病变及角膜移植片的裂隙灯显微镜图像。结果斑状角膜营养不良患者的临床表现有双眼视力进行性下降;裂隙灯显微镜检查发现双眼角膜基质雾状混浊,间以局灶性斑块或结节状灰白色混浊,斑块状混浊在中央部位于基质浅层而在周边则位于深层。在所有患者中行穿透性角膜移植术者14例(18眼),随访6至112个月,角膜植片均保持清亮。结论斑状角膜营养不良有其特征性临床表现,据此可明确诊断。对于中重度患者,穿透性角膜移植术是一种有效的治疗手段。(眼科,2006,15:169-172)更多还原

【Abstract】 Objectives To investigate the clinical feature, diagnosis and surgical treatment for macular corneal dystrophy. Design Retrospective case series. Participants 18 patients(36 eyes)with macular corneal dystrophy. Methods The clinical data of patients were studied, including history, visual acuity, slit lamp microscopy, surgical method and follow-up. Main Outcome Measures Slit-lamp microscopic images of corneal dystrophy and graft. Results The patients with macular corneal dystrophy experienced progressive loss of vision. With slit lamp microscope, opacities were observed in the entire thickness of the stroma. Irregular grey-white nodules were noted in the central superficial stroma and peripherial deep stroma. Penetrating keratoplasties were performed in 14 cases (18 eyes). The follow-up was 6-112 months. At the last follow-up, all the grafts were clear. Conclusion Macular corneal dystrophy has typical clinical features. The diagnosis is mainly based on typical clinical manifestations. Penetrating keratoplasty is an effective approach for the treatment of patients with severe macular corneal dystrophy. (Ophthalmol CHN, 2006, 15:169-172 )更多还原