【摘要】 阿尔采末病是一种进行性记忆和认知功能损伤为特征的多病因机制介导的退行性神经系统疾病,其主要病理特征为脑内老年斑沉积、神经纤维缠结以及神经元缺失变性。研究发现氧化应激,炎症反应,雌激素缺失,胆固醇代谢异常,基因突变及单胺能、谷氨酸及神经肽能神经递质功能缺损等多个环节参与其发病,针对以上各环节开展的药物治疗研究取得了长足进展。更多还原

【Abstract】 Alzheimer’s disease (AD) is a multipathogenetic and neurodegenerative illness,principally characterized by progressively,cognitive and memorial abnormalities in association with deposit of senile plaques,neurofibrillary tangles and widespread neuronal loss.Oxidative stress,inflammatory reaction,estro- gen depletion,cholesterol dysfunction,transgenation and monoaminergic,glutaminergic and peptidergic neu- rotransmitters deficits may also be the important factors in the development and progression of AD.A number of different newly created medication therapies are currently being researched to address the latest distinct aspects of the disease.更多还原