【摘要】 目的：探讨氯吡格雷对非ST抬高急性冠脉综合征病人是否能抑制动脉粥样硬化炎症反应。方法：急性冠脉综合征病人115例,分为A组(n=58,阿司匹林),B组(n=57,阿司匹林+氯吡格雷),另选C组(n= 30,健康对照)。分别在用药前、用药后7,30 d抽取空腹静脉血,检测高敏C反应蛋白(hs-CRP)和肿瘤坏死因子α(TNF-α)浓度。观察用药后30 d主要不良心脏事件(MACE)的发生情况。结果：用药前A,B两组病人血清hs-CRP,TNF-α浓度明显高于C组。用药后7 d,A和B两组病人血清hs-CRP,TNF-α的浓度降低。用药后30 d,A和B两组病人血清hs-CRP和TNF-α的浓度进一步降低,且B组较A组下降更显著(P＜0.05)。A和B两组MACE发生情况有显著差异(P＜0.05),尤其心绞痛发作B组明显低于A组(P＜0.01)。结论：氯吡格雷治疗可显著减轻动脉炎症反应,抑制动脉粥样硬化的进展,进而改善急性冠脉综合征病人预后。更多还原

【Abstract】 AIM:To investigate the effects of clopidogrel and aspirin on high sensitive C-reactive protein (hs-CRP)and tumor necrosis factor-alpha(TNF-α)in non-ST-segment elevation acute coronary artery syndromes (NSTEACS)patients.METHODS:One hundred and fifteen patients with NSTEACS were randomly divided in- to group A(n=58,treated with aspirin)and group B(n=57,treated with clopidogrel and aspirin).Thirty healthy volunteers were treated as normal control group(group C).The concentrations of hs-CRP and TNF-αwere tested before taking medicine,7 days and 30 days after taking medicine respectively.The major adverse cardiovas- cular events(MACE)were evaluated for 30 days after taking medicine.RESULTS:Before taking medicine, the concentrations of hs-CRP and TNF-αin both group A and group B were significantly higher than those in group C.Seven days after taking medicine,the concentrations of hs-CRP and TNF-αin both group A and group B decreased significantly.Thirty days after taking medicine,the concentrations of hs-CRP and TNF-αin both group A and group B decreased significantly.Compared with group A,the concentrations of hs-CRP and TNF-alpha in group B decreased significantly(P＜0.05)30 days after taking medicine.MACE was significant different be- tween group A and group B.CONCLUSION:Clopidogrel can reduce the inflammation of arteries and restrain the development of atherosclerosis.Accordingly,it improves the prognosis of NSTEACS patients.更多还原