【摘要】 p53肿瘤抑制基因突变与多数恶性肿瘤的发生发展有关,包括肝细胞癌(hepatocelluar carcinoma,HCC)在内的人类恶性肿瘤中至少有50%发生了p53基因改变。因此,以正常p53基因治疗肿瘤就成了研究热点,随着介入放射学(inter-ventional radiology)向纵深发展,经介入放射方法进行肝癌的基因治疗令人关注。本文介绍了p53基因的结构与功能,其与肝癌的病理联系以及在肝癌治疗中的应用。更多还原

【Abstract】 The suppressor mutation of p53 is relevanted with the most of malignant tumor genesis and development.At lest 50% human malignant tumors have been discovered the gene mutation of p53.So it is to be a hot spot of study at present.Following the development of interventional radiology,more and more people pay close attention to the gene therapy of HCC by intervention.This review describes the constitution and function of p53 gene,the relationship with HCC and its application in the treatment of HCC.更多还原