【摘要】 目的:探讨苯巴比妥预防早产儿脑室内出血的效果。方法:以75例胎龄≤35周的早产儿为观察对象,预防组35例接受苯巴比妥负荷量的平均时龄为生后8.2小时,维持量5天。结果:预防组的脑室内出血发生率(31%)较对照组(46%)显著降低(P<0.01),同时生后6小时内接受负荷量的脑室内出血发生率(13.6%)较对照组显著降低(P<0.01),而生后6小时以后接受负荷量的脑室内出血的发生率(61.5%)较对照组降低不明显。结论:研究显示苯巴比妥可显著降低早产儿脑室内出血的发生率。建议对胎龄≤35周的早产儿生后6小时内常规应用苯巴比妥,以期降低早产儿脑室内出血的发生率。更多还原

【Abstract】 Objective:To study the effect of Phenobarbital for the prevention Of intraventricular hemorrhage in the premature infants.Methods:A randomized controlled trail was carried out in 75 infants with a gestational age≤35 weeks,35 infants received phenobarbital as a treatment group and the other 40 as a control group,The mean age of infants being given loading of Phenobarbital was 8.2 hours.Results:The result showed that the severe intraventricular hemeorrhage occurred more frequently in infants without phenobarbital prophylaxis than in treatment infants(46% vs 31%,P<0.01).Conclusion:The study confirmed that the phenobarbital might reduce the incidence of intraventricular hemorrhage.It is suggested that phenobarbital prophylaxis should be routinly carried out in all pretem infants with gestational age≤35 weeks with 6 hours after birth.更多还原