【摘要】 目的:探讨静脉注射丙种球蛋白(IVIG)治疗早产儿败血症的疗效。方法:用单向免疫琼脂扩散法检测40例出生1￣3天(胎龄28￣36周)的早产儿血清IgG,并把这40例的败血症患儿参考相似的孕周、体重及月龄随机分为IVIG组及对照组各20例,所用的抗生素均相同,对照组加用血浆治疗,IVIG组按0.4￣0.6g/kg稀释成50ml在1￣2小时内静脉滴注。结果:出生后的早产儿IgG及其亚类随胎龄增加而升高(r=0.99,P<0.01),IVIG组治疗1周后IgG均值从5.82g/L升到13.16g/L,而对照组治疗后IgG均值仅6.24g/L,IVIG组病死率10%,对照组病死率30%(u=2.493,P<0.05),差异均有显著性。结论:IVIG治疗早产儿败血症疗效显著。更多还原

【Abstract】 Objective:In order to study the value of intravenous injection of immunogobulin (IVIG) in treating septicemia of premature infants. Methods:The serum level of IgG was determined in 40 prematures with single immuno-diffusion technique,Forty premature infants with septicemia were divided into IVIG grcup and control group.All cases were treated with similar antibiotics,Control group was treated with plasma,Immunoylobulin 0.4~0.6 g/(kg·d) was given in IVIG group by intravenous infusion with 1~2 hours for three days.Results:The serum level of IgG increased with the increase of gestational age (GA) and the mean level of IgG was positively correlated with GA (r=0.99,P<0.01).After one week of treatmeut,the mean level of IgG increased to13.16 g/L in IVIG group,much higher than 6.24g/L in the control group (P<0.01). There was significan difference between the rate of death(10%)in IVIG group and the rate of death(30%)in control group (u=2.493,P<0.05). Conclusion:It is suggested that IVIG has satisfactory therapeutic effect for treating septicemia of premature infants.更多还原