【摘要】 目的:探讨P-糖蛋白在大肠癌组织中的表达及临床诊断价值。方法:采用免疫组化SABC法检测P-gp蛋白和CEA在29例大肠癌和30例溃疡性结肠炎标本中的表达情况。结果:在大肠癌组织中P-gp表达的敏感性为65.5%,明显低于CEA的敏感性(96.8%),但P-gp的特异性为86.3%,明显高于CEA的特异性(57.6%)。在溃疡性结肠炎中P-gp表达的阳性率较低,而CEA表达的阳性率高达70%。结论:P-gp蛋白可在结肠组织中异位表达,对大肠癌的诊断特异性强、敏感性高,并可用于预测溃疡性结肠炎病变是否有癌变倾向。更多还原

【Abstract】 Objective:To explore the P-glycoprotein expression and its diagnosis value in large bowel cancers. Methods:Immunohistochemical SABC method was used for the detection of P-glycoprotein and CEA in 29 cases of large bowel cancers and 30 ulcerative colitis. Results:The sensitivity of P-glycoprotein in large bowel cancer tissue was 65.5%,significantly less than that of CEA(96.8%). But the specificity of P-glycoprotein in large bowel cancer tissue was 86.3%,significantly more than that of CEA(57.6%). The positive rate of P-glycoprotein was low in ulcerative colitis,while that of CEA was 70%. Conclusion:P-glycocprotein could ectopicly express in colon,and its diagnosis consists of high sensitivity and good specificity,could predict whether ulcerative colitis had the inclination of going malignant change.更多还原