【摘要】 目的:研究阿莫西林对小鼠肾功能的影响。方法:选择雄性昆明种小鼠,经尾静脉连续注射阿莫西林3天。观察不同剂量阿莫西林对小鼠肾功能的影响。结果:阿莫西林大剂量可引起小鼠体重下降、肾脏系数和肾损伤指标的异常,其余各实验组与对照组间差异无显著性。结论:阿莫西林大剂量可引起小鼠肾功能损害。更多还原

【Abstract】 Objective:To investigate the effect of amoxicillin on renal function in mice. Methods:Amoxicillin was consecutively injected into caudal vein in Kunming mice weighed 18 to 22 grams for 3 days,the toxic effects induced by different doses of amoxicillin.were obcerved respectively.Results:High dose amoxicillin could the decrease of mice body weight and the abnormalities of kidney coefficient and renal injury index.Conclusion:High dose amoxicillin con cause the renal functional lesion in mice.更多还原