【摘要】 目的探讨穴位埋线法抗实验性癫痫大鼠痫性发作的作用。方法将40只大鼠随机分为模型组、埋线组、西药组、针刺组,分组进行预处理后,以腹腔注射青霉素造成大鼠癫痫模型,观察各组造模后70min内痫性发作的潜伏期和痫性发作行为表现。结果埋线组、西药组、针刺组的痫性发作潜伏期均比模型组延长(P<0.05或P<0.01),其中埋线组最长,但与西药组、针刺组比较差异均无显著性意义;埋线组大鼠出现的痫性行为表现点头/甩尾、须动/头面抽动、前肢/后肢抽动、全身抽动、窜动的次数均比模型组少,整体发作程度比模型组轻,差异均有显著性意义。结论穴位埋线法可延缓癫痫的发作潜伏期、减少癫痫发作行为、减轻癫痫发作程度,具有显著的抗痫作用。更多还原

【Abstract】 Objective To study the effects of catgut implantation at acupoint on epileptic attack behavior in experimental epilepsy rats. Methods 40 rats were randomly divided into model group, catgut implantation group, western medicine group and acupuncture group. Making the acute epilepsy model by intraperitoneal injection of penicilin in rats after pretreatment, observed the latent period and the performance of epilepsy seizures within 70 minutes after intraperitoneal injection of penicilin. Results The latent period of catgut implantation, western medicine and acupuncture groups was prolonger than model group (P <0.05 or P <0.01), but there was not statistical significance among the three groups (P >0.05). The times of epileptic attack behavior in catgut implantation group including nodding/tail-flick, beard shaking, anterior/hind limb tic, systemic tic and jump was less than the model group respectively (P <0.05 or P <0.01), and the whole seizure level was less than model group too (P <0.05). Conclusion Catgut implantation at acupoint could prolong the latent period of epilepsy seizures, diminish the symptom and level of epilepsy attack, and have conspicuous anti-epilepsy effect.更多还原