【摘要】 目的研究丹龙醒脑片(DLXNP)对血瘀证家兔血液流变性和球结膜微循环的影响,以探讨其活血化瘀功效。方法从耳缘静脉注射高分子右旋糖酐(dextran500)复制血瘀证家兔模型,观察其血液流变性和球结膜微循环改变以及丹龙醒脑片对该模型的影响。结果造模后,模型组全血粘度、全血还原粘度显著升高,血沉(ESR)明显加快,血沉方程K值(ESRK)升高,红细胞聚集指数及红细胞变形指数升高,球结膜微循环形态积分和总积分明显增高(P<0.01～0.05)。与模型组相比,丹龙醒脑片各组全血粘度、血沉方程K值、红细胞聚集指数、红细胞变形指数显著降低,球结膜微循环形态积分和总积分亦有显著降低(P<0.01～0.05)。结论丹龙醒脑片能改善高分子右旋糖酐所致血瘀证家兔模型血液流变性,改善微循环障碍。这可能是其活血化瘀作用的机制之一。更多还原

【Abstract】 Objective To investigate the effects of DLXNP on hemorrheology and bulbar conjunctiva microcirculation (BCM) in rabbit and to explore its effects of activating the blood and eliminating the stagnant. Methods The blood stagnant syndrome model was reproduced by injecting dextran 500 into the marginal ear vein. The BCM and the hemorrheology properties were detected and compared. Results Compared with the normal group, the model group’s indexes of whole blood relative and whole blood reducing viscosity improved (P <0.01～0.05), erythrocyte sedimentation rate (ESR) became quicker, erythrocyte sedimentation rate K (ESRK) increased, erythrocyte aggregation index and erythrocyte transmutation index increased, BCM’s morphological mark and total mark increased (P <0.01). Compared with the modelling group, DLXNP group’s whole blood relative viscosity, ESRK, erythrocyte aggregation index, erythrocyte transmutation index and BCM’s morphological mark and totle mark decreased (P <0.01 ～ 0.05). Conclusion DLXNP can improve hemorrheology properties and regulate microcirculation of blood stagnant syndrome in rabbit model followed by injecting dextran500 into the marginal ear vein, which may be one of the mechanisms of the therapeutic actions of DLXNP.更多还原