【摘要】 目的观察原发性高血压病患者使用血管紧张素转换酶抑制剂(ACEI)依那普利后并发的醛固酮逃逸现象。方法65例原发性高血压病患者使用依那普利治疗,分别于治疗前及治疗后1、3、6个月采血,检测血管紧张素Ⅱ和醛固酮浓度,根据治疗3个月时的醛固酮浓度,判断有无并发醛固酮逃逸。结果依那普利治疗后1个月,AngⅡ、Ald与治疗前相比均下降,但3个月时,AngⅡ有所升高,Ald明显增高。65例中有28例并发醛固酮逃逸,发生率约43%。结论原发性高血压病患者长期(3个月以上)使用ACEI后,部分患者会出现醛固酮逃逸现象。更多还原

【Abstract】 Objective To investigate aldosterone escape during angiotensin-converting enzyme inhibitor(ACEI) therapy in essential hypertensive(EH) patients. Methods 65 EH patients were treated with ACEI -enalapril. Plasma angiotensin II(AngII) and aldosterone(Ald) concentrations were measured by commercial radioimmunoassay after 1,3,6 months treatment respectively.Aldosterone escape was estimated by the plasma Ald levels after 3 months treatment. Results After 1 month enalapril treatment,both the plasma AngⅡ and Ald concentrations of the patients decreased compared with before treatment. But after 3 months treatment, the plasma AngⅡ levels increased slightly, the plasma Ald levels increased significantly. Aldosterone escape was observed in 28 of 65 patients after 3 months enalapril treatment,the incidence of aldosterone escape was 43%. Conclusion Aldosterone escape may occur during continuous(>3 months) ACEI therapy in some of EH patients.更多还原