【摘要】 目的观察急性冠脉综合征患者血循环中IL-7的含量、来源及其在急性冠脉综合征中的作用。方法临床确诊为冠心病的患者75例,健康志愿者17名,测血浆及血清中IL-7含量;应用二磷酸腺苷诱导活化血小板,采用ELISA法测定活化前后血浆中IL-7的含量。结果急性冠脉综合征患者血浆IL-7浓度明显高于稳定型心绞痛患者和对照者;血小板活化后血浆中IL-7的含量明显增加。结论IL-7为冠心病一种新的生物学标志;循环中增加的IL-7主要来自血小板,IL-7参与血小板依赖的血栓形成过程,标志冠心病临床不稳定性发展。更多还原

【Abstract】 Objective To investigate the changes of IL- 7 in plasma and serum and explore the role of IL-7 in patients with ACS. Methods The trial enrolled 75 patients with documented coronary artery disease and 17 sex- and age-matched healthy volunteers. Plasma and some serum IL-7 was measured by ELISA, IL-7 in PRP after ADP-stimulated platelets also did. Results Plasma levels of IL-7 were significantly increased in patients with ACS comparing stable angia and healthy control subjects. Plasma levels of IL-7 after ADP-stimulated platelets in PRP were significantly increased. Conclusion IL-7 maybe a new biochemical marker of CAD. As suggested by the high serum levels, platelets could be an important cellular source of IL-7 in circulation,which indicate IL-7 participate in platelet-dependent thrombosis, maybe suggested the development of unvunerable plaque.更多还原