【摘要】 过氧化物酶体增殖激活受体(PPAR)是甾体激素受体超家族的新成员,能被脂肪酸以及外源性过氧化物酶体增殖剂激活,而调控参与脂类代谢的某些酶的基因表达。PPAR与心血管疾病、糖尿病、肥胖和某些肿瘤细胞的生长有密切关系。现就近年来有关PPAR与心肌肥厚相互关系的研究进展作一概述。更多还原

【Abstract】 Peroxisome proliferator-activated receptor(PPAR) is a transcription factor,belongs to the nuclear receptors family,plays a critical role in the pathophysiology of cardiac hypertrophy.PPAR manipulates cardiac energy metabolism,downregulates inflammatory response,improves insulin resistance to break vicious cycle formed by overactivated renin-angiotensin system and insulin resistance,decrease peripheral vascular resistance to reduce afterload.更多还原