【摘要】 目的了解正常新生儿生理性抗凝血因子的水平,为临床和研究工作提供参考数据。方法抽取正常足月顺产新生儿脐血及健康成人外周静脉血,分别测定抗凝血酶（antithrombin,AT）、蛋白C（protein C,PC）、组织因子途径抑制物（tissue factor pathway inhibitor,TFPI）的活性和含量,α₂巨球蛋白（α₂-Macroglobulin,α₂-MG）的含量,并与成人进行比较。结果新生儿脐血中AT、PC、TFPI的含量和活性均显著低于正常成人水平（P＜0．05）。α₂-MG的水平与正常成人相比差异无显著性（P＞0．05）。结论新生儿生理性抗凝血因子处于一个较低的水平,α₂-MG正常可能是一种代偿机制。在新生儿出血性疾病的诊断及抗凝剂的应用中应引起注意。更多还原

【Abstract】 Objective To investigate the test results of blood anticoagulant in healthy newborns to pro- vide reference data for clinic and research.Methods Activities of antithrombin（AT）,protein C（PC）,tis- sue factor pathway inhibitor（TFPI）and changes of AT,PC,TFPI andα₂-macroglobulin（α₂-MG）,were measured in healthy neonates and in healthy adults.Results Compared with healthy adults,activities of AT,PC,TFPI and changes of AT,PC and TFPI were significant lower（P＜0.05）.Change ofα₂-MG was lower slightly（P＞0.05）.Conclusion Anticoagulant functions were at a lower level and the level ofα₂-MG maybe one saving mechanism which provides a information for diagnoses of neonatal hemorrhagic diseases and use of anticoagulant in clinic.更多还原