【摘要】 目的研究急性淋巴细胞白血病(ALL)患儿使用左旋门冬酰胺酶(L-ASP)中凝学象的变化。方法27例ALL患儿,以Clauss凝固法测定血浆凝血酶原时间(PT)；活化部分凝血活酶时间(aPTT)以及纤维蛋白原(Fbg)。结果27例ALL患儿共51人次在使用L-ASP中,凝血检查结果均出现异常。Fbg为敏感的指标,其中使用剂量为2万u/m~2时患儿60．3%(31/51例)出现Fbg下降,而使用剂量为4万u/m~2时患儿86．3%(44/51例)出现Fbg明显下降。结论ALL患儿在使用L-ASP治疗中容易出现Fbg下降,下降程度与剂量相关,PT与aPTT不受其影响。检测凝血象对掌握病情,药物使用安全性有重要价值。更多还原

【Abstract】 Objective Study blood coagulation function for acute leukemia patient under the therapy of L-Asaraginase(L-ASP).Methods 27 patients of acute leukemia,undergo the test of prothrombin time,acti- vated partial thromboplastin time and plasma fibrinogen by claus’s methods.Results 27 patient in 51 times L- ASP procedure shows abnormal.Fbg is the most sensitive,with dosage 20 000 u/m~2 60.3% (31/51 case) shows decrease of the level of Fbg,and with dosage 40 000 u/m~2 86.3% (44/51 case) shows significant decrease. Conclusion acute Leukemia patient under the therapy of L-ASP are ease to get decrease of the level of Fbg, the severity of decline is relate to L-ASP dosage.PT,aPTT are not related to L-ASP usage.Blood coagulation function test is important for monitor of process in therapy,and the safe use of medicine.更多还原