The asymmetric reduction of ketosulfone with borane catalyzed by oxazaborolidine is computed by means of the semi-empirical MNDO method.As shown,this asymmetric reduction is exothermic.The chirality-controlled step for this reduction is the hydride transfer from the BH_3 moiety to the carbonyl carbon of ketosulfone.The hydride transfer is irreversible and is realized via a transition state with a six-membered ring.
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