【摘要】 目的探讨脂糖舒对糖尿病大鼠胰岛β细胞自由基损伤的保护作用。方法腹腔注射链脲酶素制作糖尿病大鼠模型。用不同剂量脂糖舒(0.5g/kg和1.0g/kg)灌胃,连续8周,并取健康大鼠作正常对照。8周后,测定各组大鼠血清葡萄糖(G lu)、胰岛素(Ins)和胰岛组织的丙二醛(MDA)含量及超氧化物歧化酶(SOD)活性并计算胰岛指数。结果大剂量脂糖舒组血清Ins含量和胰岛组织SOD活性显著增高;血清G lu和胰岛组织MDA含量显著降低,且升高SOD活性和降低血清G lu和胰岛组织MDA含量的作用优于其小剂量组。结论脂糖舒对糖尿病大鼠胰岛β细胞自由基损伤有明显的保护作用和促进胰岛素分泌的作用。更多还原

【Abstract】 Objective To study the protective effects of Zhitangshu(ZTS)On islet β cells injury of diabetic rats caused by free radicals.Methods The diabetic model was established by abdominal injection of streptozotocin(50mg/kg) in rats.Then,different doses of ZTS 0.5g/kg in ZTS-1 group and 1.0g/kg in ZTS-2 group were respectively perfused into stomach for 8 weeks,and healthy rats were used as control.After 8 weeks,the contents of Glucose(Glu),Insulin(Ins)in serum and malondialdehyde(MDA)in islet tissues and the activity of superoxide dismutase(SOD)in islet tissues were detected and the islet index was counted.Results ①The contents of Ins and the activity of SOD and islet index were obviously increased,but Glu was decreased in ZTS-2 group(P<0.05~0.01 vs diabetic control group).②The effects of increasing SOD as well as of decreasing Glu and MDA in ZTS-2 group were better than that in ZTS-1 group.Conclusion ZTS has obvious effects of promoting insulin secretion and protecting islet β cells injury of diabetic rats caused by free radicals.更多还原