【摘要】 目的观察氧化苦参碱对青霉素致痫大鼠血清中细胞因子的影响。方法腹腔注射青霉素制备癫痫动物模型,测定腹腔内注射氧化苦参碱(OMT)后的癫痫大鼠血清中肿瘤坏死因子(TNFα)、白介素2(IL-2)、白介素6(IL-6)的含量。结果癫痫大鼠血清中TNFα、IL-2、IL-6含量升高;OMT腹腔内注射可降低癫痫大鼠血清中TNFα、IL-2、IL-6含量。结论氧化苦参碱抗癫痫作用机制中有细胞因子的参与。更多还原

【Abstract】 Objective To study the influence of oxymartrine on cytokine in blood serum of penicillin induced epilepsy in rats.Methods Penicillin was injected into the abdominal cavity of rats to make epilepsy model,and to measure the contents of TNFα,IL-2 and IL-6 in serum of epilepsy rats.Results The contents of TNFα,IL-2 and IL-6 in serum of epilepsy rats increased.OMT injected in abdominal cavity of epilepsy rats can lower the contents of TNFα,IL-2 and IL-6.[WT5H1]Conclusion Cytokines take part in the mechanism of anti-epilepsy of oxymartrine.更多还原