【摘要】 蛋白粒子主要引起人和动物的中枢神经系统退行性疾病,称之为蛋白粒子病。许多研究表明蛋白粒子病的致病因子缺乏棱酸,而是由特异的传染性蛋白质组成。该蛋白粒子是一种膜糖蛋白,至少有两种基本形式,即PrP^c和PrP^ac。PrP^ac是发病的直接原因,而PrP^c向PrP^ac转变则是发病的必要条件。文章就蛋白粒子概念、分子生物学以及全新的传染机制作了综合论述。更多还原

【Abstract】 Prion mainly causes the diseases of central nervous system in human and animal.Much evidence supports the hy- pothsis that the infectious agents of prion diseases are devoid of nucleid acid and instead are composed of a specific infections proteion.The prion protein is a membranous glycoproteit which has at least tow radical forms,PrP^c and PrP^ac PrP^ac is the di- rect reason of leading to the diseases pathogenicity of prion lies in normal P,p^c transforning in to abnornal P_r P^ac This revivew was involved with the conception,molecular biology,new infection mechanism of prion.更多还原