【摘要】 常规饲养条件喂养的大群AA肉鸡,按临床症状分为肺动脉高压组(M组),肺动脉高压腹水组(S组)和正常对照组(C组)。分别测定21、28、35和42日龄S组、M组和C组肉鸡的腹水心脏指数(AHI)、全心与体重比(WH/BW)、平均肺动脉高压(mPAP)、血清一氧化氮(NO)水平、肺脏和血清cNOS和iNOS活性。试验结果表明:(1)S组和M组全心与体重比值(TV/BW)以及S组血清NO水平均从28日龄起显著或极显著高于C组(P<0.01或P<0.05);(2)S组肺组织cNOS水平显著或极显著低于C组(P<0.01或P<0.05);(3)S组肺组织iNOS在21、35和42日龄显著或极显著高于C组(P<0.01或P<0.05);(4)S组从28日龄起血清中cNOS和iNOS与C组差异显著或极显著(P<0.01或P<0.05);(5)正常对照组肉鸡血清中iNOS活性在21、35和42日龄均显著或极显著低于血清中cNOS活性(P<0.01或P<0.05)。此研究结果提示cNOS和iNOS活性的变化与PHS发病机理有着密切的关系,并在其中发挥着重要的作用。更多还原

【Abstract】 A large group of commercial broilers that were raised according to AA feeding condition were divided into hypertension and ascites group(group S),hypertension group(group M) and control group(group C).The activities of iNOS and cNOS in lung and serum of boilers in group S,M and C were measured at the age of 21,28,35 and 42 days.AHI,WH/BW,mPAP and nitric oxide(NO) in serum were measured as well.Results were as follows:(1) From the age of 28 days,the WH/BW of group S and group M and the NO level in serum of group S were higher or significantly higher than that of group C(P<0.01 or P<0.05);(2) The cNOS activity in lung of group S was lower or significantly lower than that of group C(P<0.01 or P<0.05);(3) At 21,35 and 42 days old,the iNOS activity in lung of group S was higher or significantly higher than that of group C(P<0.01 or P<0.05);(4) From the age of 28 days,the cNOS and iNOS activities in serum differed significantly or very significantly between group S and group C(P<0.01 or P<0.05);(5) The iNOS activity was lower or significantly lower than cNOS activity in serum of group C at the age of 21,35 and 42 days(P<0.01 or P<0.05).It was suggested that the changes of cNOS and iNOS activities play a role in the development of PHS.更多还原