【摘要】 目的观察阿托伐他汀对急性心肌梗死患者血清一氧化氮(NO)及一氧化氮合酶(NOS)水平的影响。方法急性心肌梗死患者分为两组,治疗组入院后予阿托伐他汀10mg QN,对照组予常规治疗。治疗前及治疗后2周测定血清NO及NOS含量水平。结果阿托伐他汀可以提高急性心肌梗死患者血清NO及NOS水平。结论阿托伐他汀通过诱导血管内皮细胞分泌NO,保护血管内皮功能,对急性心肌梗死的治疗具有重要意义。更多还原

【Abstract】 Objective To investgate the influence of atorvastatin on serum nitric oxide and nitric oxide synthase in patiens with acute myocardial infarction.Methods 82 cases of acute myocardial infarction were randomized into 2 groups,therapy group(n=41) and control group(n=41).Patients of therapy group were given atorvastatin 10mg/d at night.Serum level of NO and NOS were measured after 2 weeks.Results Compare with those before treatment,the serum levels of NO and NOS were increased significantly after treatment in therapy group(P<0.05).There was no significant change in control group.Conclusion Atorvastatin induces endothelium to secret NO.Treatment of atorvastatin protect endothelial function.更多还原