【摘要】 目的:探讨血管紧张素Ⅱ1型受体(AT1R)A1166C多态性与高血压、高血压肾脏损害的关系。方法:入选188例原发性高血压患者进行尿微量白蛋白和AT1R基因A1166C多态性测定。结果:AA基因型与AC基因型收缩压分别为(149·1±20·8)mmHg(1mmHg=0·133kPa)和(137·8±22·6)mmHg,2组间差异有显著性(P=0·013)。AC基因型携带者尿微量白蛋白尿异常者明显增多,差异有显著性(P=0·006)。结论:AT1R基因A1166C多态性可能与原发性高血压和高血压肾脏损害有关。更多还原

【Abstract】 Objective:To investigate the relationship between angiotensin Ⅱ type 1 receptor(AT1R) gene A1166C polymorphism and renal damage in essential hypertension.Method:188 patients with essential hypertension were enrolled into this study. Every people measured microalbuminuria. Genomic DNA was extracted from peripheral blood leukocytes by standard method. Polymerase chain reaction(PCR)combined with restriction enzyme digestion was used to detect the polymorphism. Result: SBP in AA genotype was significantly higher than AC genotype(P=0.013). The subjects with microalbuminuria increased significantly in AC genotype(P=0.006).Conclusion:AT1R gene A1166C polymorphism may be possibly related to was associated with essential hypertension and its renal damage.更多还原