【摘要】 谷胱甘肽硫转移酶(gluth ione S-transferase,GST)是一种广泛存在于各种生物组织中的小分子水溶性蛋白.GST属于II相代谢酶,主要功能是催化某些内源性或外来有害物质的亲电子基团与还原型谷胱甘肽的巯基结合,增加其疏水性使其易于排出体外,同时某些GST还具有谷胱甘肽过氧化酶活性.本文着重介绍了近年来国内外对水生动物GST的基础研究包括组织分布、同工酶类型和结构基因研究,以及各种环境污染物对水生动物GST的影响,探讨其作为生物标志物的可行性.更多还原

【Abstract】 Gluthione S-transferases(GSTs) are soluble protein with low molecular weight,present ubiquitously in all kinds of organic tissues.GSTs are a family of detoxification enzymes that catalyze the conjugation of glutathione(GSH) to endogenous or xenobiotic electrophiles,thus preventing toxicity.And some GST isoenzymes have antioxidantase activity,so they maybe play an important role in detoxifcate metabolism.This paper review the recently native and foreign research of gluthione S-transferase in aquatic animal,including the base research of GST such as tissue distribution,isoenzyme classify,structure gene and the effect of environmental pollutant on GST.The suitability of GST to be biomarker is also discussed.更多还原