【摘要】 目的:探索大鼠马桑内酯癫痫点燃模型脑部星形胶质细胞及毛细血管内皮细胞P-170的表达。方法:用发作级数评分观察马桑内酯点燃大鼠,免疫组化法测定P-170蛋白的表达。结果:点燃大鼠脑部广泛区域的P-170表达较未点燃大鼠和正常大鼠显著增强,P-170的表达与马桑内酯(CL)的剂量无相关性(P>0.05)。结论:SD大鼠马桑内酯癫痫点燃模型可用于建立一种耐药性癫痫模型。更多还原

【Abstract】 Objective:To detect the expression of P-170 in astrocytes and capillary endothelial in brains of SD rats kindled by Coriaria Lactone.Methods:The rats was observed by identifying the seizure stages and the expression of P-170 in the brains of all rats was tested by immunohistochemistry method.Result:Compared with unkindled rats and placebo rats,the expression of the P-170 staining in the brain samples of kindled rats were significantly increased.No dose relation has been observed in the staining area of P-170 in astrocytes of the brain samples from kindled rats(P>0.05).Conclusion Kindling SD rats induced by intramuscular injection of CL can be used as an animal models of intractable epilepsy.更多还原