【摘要】 目的:观察肠炎康对溃疡性结肠炎动物的功效和作用机理。方法:采用三硝基苯磺酸法制备大鼠实验性溃疡性结肠炎模型,观察各组结肠病理损伤,IL-1B、TNF-a、SOD、MDA等指标的变化;并观察肠炎康对小肠推进运动、炎症和疼痛的影响。结果:肠炎康能减轻溃疡性结肠炎的病理损伤;显著降低溃疡性结肠炎大鼠血清IL-1B、INF-a、结肠组织MDA含量,而提高SOD含量;能明显降低小肠内墨汁推进率,减慢小肠蠕动速度;能降低毛细血管的通透性,具有一定的抗炎作用;对化学因素引起的疼痛有较好的镇痛作用。结论:肠炎康有减轻结肠炎症损伤、减轻氧自由基的损害、解痉、抗炎镇痛的作用。更多还原

【Abstract】 Objective:To investigate the effects and mechanism of Changyankang Decoction on chronic ulcerative colonitis.Methods:The rat ulcerative colonitis model was made with TNBS.The pathology of colon,IL-1B,TNF-α,SOD and MDA were measured in all groups,and the effect of the drug on movement of small intestine,inflammation and pain were observed.Results:The drug could alleviated pathologic damage of ulcer ative colonitis;debased IL-1B,TNF-α in serum and MDA in colon,increased SOD in colon;depressed pushing rate of ink in small intestine,reduced penetration of capillary,resisted inflammation;lessened the pain arosed by chemicals.Conclusion:Changyankang decoction could alleviate pathologic damage and oxygen free radical damage to ulcerative colonitis,and it is effective to reduce intestine spasm,to resist inflammation and to lessen the pain.更多还原