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壳聚糖排铅效果的临床观察

The effect of chitosan in the treatment of lead-elminating

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【作者】 王英赵斐江凌圳

【Author】 WANG Ying~(1),ZHAO Fei~(2),JIANG Ling-zhen~(1)(1.Zhejiang Institute of TCM,Hangzhou 310007,China;2.Zhejiang Pharmaceutical Co.Ltd.,Hangzhou 310003,China)

【机构】 浙江省中医药研究院浙江医药股份有限公司浙江省中医药研究院 杭州310007杭州310006杭州310007

【摘要】 目的观察壳聚糖的排铅效果。方法选择100例高铅儿童(血铅高于10.0μg/d l),按血铅水平均衡地随机分组,其中对照组50例,试验组50例。试验组服用壳聚糖(推荐剂量为每日1.5g)配制的牛奶,对照组服用普通牛奶,服用一个月。结果壳聚糖能显著降低高铅儿童的血铅含量(P<0.05),增加尿铅排出量(P<0.05),而对尿钙和尿锌排出量无显著变化(P>0.05)。结论壳聚糖具有促进排铅作用。

【Abstract】 OBJECTIVE To study effect of chitosan in the treatment of lead-eliminating.METHODS 100 high-lead childrens(blood lead level>10.0μg/dl) were divided randomly according their blood lead level into 2 groups.50 childrens with chitosan and 50 childrens as control.Chitosan milk had been administrated to the test groups daily(1.5g/d) for 1 months while the nomal milk had been administrated to the controls instead. RESULTS Chitosan could not only decrease the blood lead of the high-lead children(P<0.05),but increase the excretion of urine lead(P<0.05).The eliminating of urine calcium and the urine zinc had no obviously change(P>0.05).CONCLUSION Chitosan milk could improved the effect of leadeliminating.

【关键词】 排铅高铅儿童壳聚糖
【Key words】 lead-eliminating high-lead childrenchitosan
【基金】 国家自然科学基金资助项目(编号:39570874);浙江省科技厅重点资助项目(编号:956009A)
  • 【文献出处】 中国现代应用药学 ,Chinese Journal of Modern Applied Pharmacy , 编辑部邮箱 ,2006年S1期
  • 【分类号】R725.9
  • 【被引频次】2
  • 【下载频次】129
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