【摘要】 目的观察蒙药童格勒格-1(TGLG-1)对高脂血症大鼠血清血脂的调节作用。方法建立大鼠高血脂模型。高血脂症大鼠分为四组,一组为实验对照组,其余三组分别以低、中、高剂量TGLG-1灌胃,21d后测定血脂值。结果与高脂对照组相比,中、高剂量TGLG-1能显著降低血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白一胆固醇(LDL-C)水平。结论TGLG-1具有良好的降低血脂浓度和预防高血脂症的作用。更多还原

【Abstract】 OBJECTIVE To study the adjustive effect of TGLG-1 on the level of serum lipids in hyperlipidemic rats.METHODS The model of hyperlipidemic rats were established.The experimental hyperlipidemic rats were divided into four groups.Among them,one group was received physiological saline by ig administration as hyperlipidemic control.The other three groups were respectively treated with TGLG-1(4g/kg,8g/kg,16g/kg) by ig administration.After 21 days treatment,the serum lipids of each group were determined. RESULTS Compared with the hyperlipidemic control group,it is found that TGLG-1 could significantly decrease the level of cholesterol(TC),triglyceride(TG) and low density lipoprotein.cholesterol in the serum of experimental groups,as well as remarkably increase the level of high density lipoprotein.cholesterol and the value of(HLD-C)/TC in the serum of the hyperlipidemic rats.CONCLUSION TGLG-1 has the effect to decrease the content of the serum lipids and prevent hyperlipidemia disease.更多还原