【摘要】 目的:测定神经症患者头发中钙、锌、铁、铜、镁的含量,分析其是否异常以及可否用于神经症的辅助诊断。方法:连续登记2001-06/2003-03在驻马店市精神病医院神经内科住院的符合纳入标准的患者652例。以出院诊断为神经症的337例作为神经症组,以出院诊断除外入院时疑为神经症的其他神经科疾病者315例作为病例对照组。健康对照组选用本实验室成年组常模。剪取患者头发约0.5g,用原子吸收分光光度计测定。实测值低(高)于本实验室相应的参考值(常模的数据)下(上)限者占相应总数的百分率为低(高)于正常率;实测值不在参考值范围内者占相应的总数百分率为总异常率;5种元素至少有一种异常的百分率是同组中元素含量不完全正常的人数占相应总数的百分率。实测值超出参考范围者记为异常,异常程度=(实测值-参考值)/相应值的标准差,取其绝对值。结果:652例患者均完成各项指标的测定,全部进入结果分析。①元素含量与健康对照比较,神经症组男性钙、铁、镁含量降低,锌含量增高,女性钙、锌、铁、铜、镁含量均降低。与病例对照组的比较,男性铁含量降低,女性镁含量降低。②各组异常率:神经症组与健康对照组比较钙、锌、铁、铜、镁总异常率差异均有显著性意义(P≤0.001)。与病例对照组比较钙的总异常率差异有显著性意义(P=0.003),且以低于正常率为显著(P=0.008)。③各组男性异常率:神经症组与健康对照组比较,钙、锌、铁、铜、镁各元素低于正常率和总异常率均高(P=0.000)。与病例对照组相比,铁低于正常率和总异常率高。④各组女性异常率:神经症组与健康对照组比较,锌、钙、铁、铜、镁各元素低于正常率和总异常率高(P=0.000);钙、铁、铜、镁高于正常率高(P<0.05)。与病例对照组比较,钙低于正常率和总异常率高(P<0.05)。⑤5种元素至少有一种异常的百分率:健康对照组头发中5种元素含量中至少1种异常的例数为8例,异常率为5%,神经症组异常数326例,异常率96.7%,病例对照组异常数298例,异常率94.6%,各组异常率差异有显著性意义(P=0.000);卡方分割进行两两比较时表明神经症组与病例对照组差异无显著性意义(P>0.05),神经症组、病例对照组都与常模组差异有显著性意义(P=0.000)。⑥相关性:多元逻辑回归分析显示神经症组和病例对照组与钙是否异常相关(P=0.007),与钙、锌、铁、铜、镁各元素含量和异常程度不相关。结论:本组测定结果中患者头发中的锌、钙、镁、铜、铁5种元素既有升高也有降低。钙、镁、锌、铜、铁5种元素的改变不是神经症的特异改变。更多还原

【Abstract】 AIM:To detect the contents of calcium,zinc,iron,copper and magnesium in hairs of patients with neurosism,and analyze whether they are abnormal and can they be used for diagnosis of neutosis.METHODS:652 inpatients in accordance with the criteria were selected from the Department of Neurology of Zhumadian Mental Hospital between June 2001 and March 2003.337 subjects diagnosed as neurosis at discharge were taken as the neurosis group,and 315 patients with other neural diseases,who were suspected of neurosis and proved to be without neurosis at discharge,were taken as the disease control group.Normal models were taken as healthy control group,whose hairs were cut off for about 0.5 g.The contents of zinc,calcium,iron,copper and magnesium were tested with atomic absorption spectrophotometer.The percentage of those with the measured value lower(higher)than the minimum(maximum)reference value of the laboratory(data of normal model)was lower(higher)than the normal rate.The total percentage of those with the measured value above or below the reference range was the total abnormal percentage rate.The abnormal percentage rate of at least one element out of five was the percentage of subjects of the same group with incomplete content of element.The measured value,exceeded the range of reference was considered as abnormal.The abnormal degree =(measured value-reference value)/standard diviation(SD)of corresponding value,and the absolute value was required.RESULTS:652 patients were involved in the analysis of results,who had accomplished the determination of each index.①Comparison in content of elements with control group:the contents of calcium,zinc,iron and copper in males of neurosis group were increased,while those in females were decreased.Compared with the disease control gorup,the content of iron was decreased in males of neurosis group,and the content of zinc in females was reduced in neurosis.②Abnormal rate in each group:there were significant differences in abnormal rate of calcium,zinc,copper and iron between neurosis group and healthy control gorup groups(P ≤ 0.001),and the differences in abnormal rate of calcium compared with the disease control group were remarkable(P=0.003),moreover,those below the normal rate was the most significant(P=0.008).③The abnormal rate in man of each group:the content of five elements lower than the normal rate and total abnormal rate were higher in the neurosis group than the healthy control group(P=0.000),and the content of iron lower than the normal rate and total abnormal rate was higher than the disease control group.④The abnormal rate of woman in each group:the content of five elements lower than the normal rate and total abnormal rate were higher in the neurosis group than the healthy control group(P=0.000),and the contents of calcium,iron,copper as well as magnesium higher than the normal rate were higher than the healthy control group.Compared with the disease control group,the content of calcium lower than the normal rate and total abnormal rate were higher(P < 0.05).⑤The percentage of abnormal in at least one element:8 subjects in the healthy control group were abnormal in at least one element with the abnormal rate of 5%,and that in the neurosis group was 326 cases with the abnormal rate of 96.7%.298 patients represented this phenomenon with the abnormal rate of 94.6%,and there were significant differences in abnormal rate among each group(P=0.000).Comparions between each two groups by partition of Chi-square:there were no marked significance between neurosis group and disease control group(P > 0.05),while there were remarkable differences between either neurosis group or disease control group and normal model group(P=0.000).⑥Correlation:multielement logistic regression analysis showed that the abnormality of calcium related with neurosis group and disease control group(P=0.007),but there were no correslation between contents of calcium,zinc,iron,copper as well as magnesium and the abnormality.CONCLUSION:There are both decrease and increase of five elements in hairs of patients in the neurosis group.The change of five elements is not the specific change of neurosis.更多还原