【摘要】 目的评价羊水穿刺术在产前诊断胎儿染色体异常中的应用。方法对234例有产前诊断指征的孕妇在超声引导下经腹羊膜腔穿刺抽取羊水检查染色体核型,并比较不同产前诊断指征分组的异常染色体检出率。结果全部病例穿刺均成功,羊水细胞培养成功率97.86%,染色体异常检出率5.68%。其中超声示胎儿异常组染色体异常检出率(33.33%)明显高于21-三体高风险组(4.54%)、不良孕产史组的检出率(9.09%)(P<0.05)。结论超声引导下经腹羊膜腔穿刺抽取羊水在产前诊断中是成熟有效的操作技术,孕妇血清学筛查异常、不良孕产史、超声示胎儿异常是有效的穿刺指征,其中胎儿异常的超声监测对产前诊断提示胎儿染色体异常具有较好的预测性。更多还原

【Abstract】 Objective:To evaluate the role of percutaneous ultrasound-monitored amniocentesis in the prenatal diagnosis of the fetal chromosomal abnormalities.Methods:Percutaneous ultrasound-monitored amniocentesis was performed on 234 pregnant women with indications for prenatal diagnosis to detect karyotype of the fetus.The detection rate of the chromosomal abnormality was compared in different groups.Results:All the cases were punctured successfully.The archievement rate of the aminiotic fluid was 97.86%,and the detection rate of the chromosomal abnormality was 5.68%.The detection rate of the chromosomal abnormality of the abnormal fetus detected by ultrasound (33.33%) was higer than the trisomy 21 high risk group(4.54%) and abnormal delivery group(9.09%)(P<0.05).Conclusion:The percutaneous ultrasound-monitored amniocentesis proves to be valid in the prenatal diagnosis.The valid indications of the puncture include the abnormal serology screening results of pregnant women,the history of abnormal deliveries and the abnormal fetus detected by ultrasound.The ultrasound detection of the abnormal fetus have better predictability to the prenatal diagnosis of fetal chromosomal abnormality.更多还原