【摘要】 在蛋白质的可逆磷酸化过程中,蛋白激酶和蛋白磷酸酶有着同等重要的作用。近年来,人们逐渐把研究的重点转移到以往关注甚少的蛋白磷酸酶家族上。蛋白磷酸酶4(PP4或PPX)是蛋白磷酸酶2A(PP2A)家族的重要成员之一,它与多个调节亚基形成多种复合体参与诸多重要的细胞进程,如中心体的成熟、剪接体复合体的组装、多个细胞信号通路的调节以及DNA损伤修复的调节等多个事件。现对PP4的组成、活性调节及已知的生物学功能作简要介绍。更多还原

【Abstract】 Protein kinase and phosphatase played equal role in reversible phosphorylation. Recently, focuses transferred from kinase to phosphatase which used to be neglected. Protein phosphatase 4 (PP4 also called protein phosphatase X) is an important member of protein phosphatase 2A family. It formed multiple complexes with different regulatory subunits and participated in many cellular progresses such as centrosome maturation, spicesome assembly, regulation of many pathways and regulation of DNA damage and repair. The paper focuses on the composition, activity regulation and known biological functions of PP4.更多还原