【摘要】 目的了解北京市男男性接触者(MSM)的艾滋病病毒(HIV)感染及宿主的免疫状态。方法2005年7~12月对招募的MSM进行HIV感染检测,采集阳性感染者的外周血,对分离毒株进行鉴定,并对阳性感染者的免疫状态包括CD4+、CD8+T细胞的数量,以及感染者体内病毒载量进行了分析。结果在招募的526名MSM中,HIV感染的主要流行亚型为欧美B亚型,1例为CRF01-AE重组亚型,后者主要为异性间HIV感染的流行亚型。HIV感染者中合并HCV或者梅毒的感染率分别为17.65%与35.29%,合并感染者的CD4+、CD8+T淋巴细胞数量明显降低,病毒载量明显升高。结论MSM人群中HIV感染者合并STD感染,明显降低宿主免疫系统控制病毒复制的能力,同时存在着MSM人群与其他高危人之间通过性途径相互传播HIV的趋势。更多还原

【Abstract】 Objective To elucidate HIV infection and immunity status among men who have sex with men（MSM）in the face of an increasing risk of HIV-1 infection by both hetero-and homo-sexual transmission accounting for 43.6% of overall HIV infection.Method HIV infection was tested among recruited MSM in Beijing and their blood specimens were collected and virus strains were solated and tested.Immunity status including CD⁺₄,CD⁺₈ T cell counts and viral loads was assayed in those with positive HIV antibodies.Result Of the 526 MSM individnals 17 were confirmed as HIV-1 positive,and the co-infection rates with HCV or syphilis among them were 17.65% and 35.29%,respectively.The amounts of both CD⁺₄ T cells and CD⁺₈ T cells were significantly decreased in HIV positive cases co-infected with HCV or syphilis,and their viral loads were increased by 6～7 folds accordingly.The circulabng HIV-1 strains isolated in this population group were identified as HIV-1 subtype.In contrast to teports of heterosexual transnission of subtype CRF01-A/E HIV-1 and min cnculaling subtype B/C in China,most of the circnlating virus strains in our study populstion were subtype B,and one was subtype CRF01-A/E.Conclusion Coinfection of HIV with STDs has obviously decreased mmunity against virus replication in MSM population group,and there is a tendency of spreading HIV infections through sex between MSM and other high risk population groups.更多还原