【摘要】 目的观察血府逐瘀汤对家兔心肌缺血再灌注损伤的保护作用。方法结扎家兔左冠状动脉前降支制备缺血再灌注模型,观察血府逐瘀汤对家兔血清中磷酸激酶(CPK〕、心肌组织的丙二醛(MDA)、超氧化物歧化酶(SOD)、肌酸激酶(CK)含量的影响;对心电图ST段的影响。结果血府逐瘀汤各剂量组家兔血清中CPK含量明显低于模型组(P<0.01);心肌组织MDA低于模型组(P<0.01),SOD、CK明显高于模型组(P<0.01);ST段抬高的程度呈下降趋势。结论血府逐瘀汤对心肌缺血再灌注损伤有较强的保护作用。更多还原

【Abstract】 Objective To observe the effect of Xuezhuyutang on protection of the myocardium against ischemia-reperfusion injury in rabbits.Method Established models of ischemia-reperfusion injury by the branch-ligation of left coronary artery.The contents of phosphokinase(CPK)in serum,malˉonic aldehyde(MDA),superoxide dismuase(SOD)and CK in myocardium tissue,the shape of ST segment in ECGs was measured.Results The content of CPK in serum,MDA in myocardium tissue in Xuefuzhuyutang groups were obviously lower(P<0.01),but the content of CK,SOD is higher obviˉously than those in the model group(P<0.01),the rising of ST segment in ECGs showed a downˉward trend.Conclusion Xuefuzhuyutang has an obvious protective effect on myocardium against isˉchemia-reperfusion injury.更多还原