【摘要】 目的探讨碘缺乏对轻度听力障碍的致病机理以及轻度听力障碍对亚克汀病诊断的有效性。方法对宁强试验区亚克汀病可疑儿童和正常对照组儿童,分别于1996,1999年做听力检查。结果①在试验区处于补碘不足时期(1996),亚克汀病可疑儿童的纯音听阈异常率显著高于正常对照儿童(P<0.01),且其听力损失多发生在低频区(500 Hz);②在试验区处于补碘正常时期(1999),两组儿童的听力异常率已无显著性差异(P>0.05);③同一组儿童1996和1999年前后两次的听力复查结果相比较,1999年其听力出现明显好转且以低频区提高的幅度最大。结论随着补碘正常,有听力障碍的儿童听力明显好转,部分已恢复正常,提示轻度听力损伤是由于当前缺碘导致激素性甲状腺功能低下引起的耳蜗膜迷路积水的结果。在补碘正常后,轻度听力障碍已不再和因过去缺碘造成的脑与神经损伤所致的精神发育迟滞相关联,因而已不宜用轻度听力障碍来辅助诊断亚克汀病患儿。更多还原

【Abstract】 Aim To investigate the disease reason of mild audition handicap and the validity of mild audition handicap to diagnose the sub-cretin.Methods Audition examination was tested for suspicious sub-cretin children and their control group in 1996 and 1999 in Ningqiang county.Results ① In the period of iodine inadequate in 1996,the sub-cretin children′s abnormal rate of pure tone hearing threshold was significantly higher than their control group(P<0.01) and their audition damage frequently happened in low frequency region(500 Hz);② In the period of adequate supplementation of iodine in 1999,the abnormal rate of tone hearing threshold had no significant difference(P>0.05) between two groups.③ Compared aith the audition examination results between the same group children in 1996 and 1999,the children′s audition was clearly improved and the enhance range was most obviously in low frequency region in 1999.Conclusion With the supplementation of iodine as normal,the audition handicapped children′s audition is clearly improved,part of them is already recovered,it suggest that mild audition damage is caused by iodine deficiency that leads to hypothyroid which result in cochlea membranous labyrinth.In the period of adequate supplementation of iodine,there is no correlation between the audition handicap and the mental retardation.So,it should not use audition handicap to diagnose the sub-cretin children.更多还原