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槲皮素对大鼠骨骼肌脂质过氧化影响研究

Effect of quercetin on lipid peroxidation in muscle of trained rat

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【作者】 董改宁; 刘海英; 朱长跃;

【Author】 DONG Gai-ning~1,LIU Hai-ying~2,ZHU Chang-yue~3(1.Department of Physical Education,Chang′an University,Xi′an 710061,China;2.College of Life Science,Shaanxi Normal University,Xi′an 710062,China;3.Xi′an Jiaotong Uiversity,Xi′an 710049,China)

【机构】 长安大学公共体育部; 陕西师范大学生命科学学院; 西安交通大学体育部 陕西西安710061; 陕西西安710062; 陕西西安710049;

【摘要】 目的研究抗氧化剂槲皮素对大鼠运动能力的影响。方法以跑台训练建立动物模型,测定了大鼠运动力竭时间和肌糖原含量、骨骼肌组织超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA)含量及血清肌酸激酶(CK)的活性。结果服用槲皮素后大鼠力竭时间明显延长;肌糖原含量升高;力竭即刻骨骼肌组织SOD,GSH-Px活性升高,MDA含量显著降低,血清酶CK活性的上升幅度显著降低。结论槲皮素能通过增加肌糖原含量,减轻骨骼肌自由基损伤来提高大鼠的运动能力,可作为一种运动保健品开发利用。

【Abstract】 Aim To study the effect of quercetin on exercise performance and protecting tissues from sports injury.Methods By setting up endurance training+axhaustive exercise model,some indices in rat are measured including muscle glycogen content,activity of SOD,GSH-Px in muscle and serum CK.Results Compared with control groups quercetin obviously prolongs exhausetive exercise time;increases musscle glycogen content;remarkably restains the decreased activity of SOD,GSH-Px and increased activity of MDA in muscle after exhaustive exercise.Conclusion Quercetin,one kind of effective anti-oxidative substance,can improve exercise performance in trained rat by increasing muscle glycogen and relieving sports injury of muscle tissue,hence,it will be explored as sports healthy food.

【基金】 陕西省自然科学基金资助项目(2003C137)
  • 【文献出处】 西北大学学报(自然科学版) ,Journal of Northwest University(Natural Science Edition) , 编辑部邮箱 ,2006年04期
  • 【分类号】G804.7
  • 【被引频次】5
  • 【下载频次】135
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