【摘要】 目的研究合成新生物活性化合物。方法DL-高半胱氨酸硫内酯(3-氨基-二氢噻吩-2-酮)盐酸盐与取代苯甲醛反应,通过优化反应条件,得到3-氨基-二氢噻吩-2-酮类Schiff碱,新化合物结构进行了IR,1H NMR和元素分析。结果合成了6个未见文献报道的新Schiff碱类化合物。结论本文报道的合成方法具有反应条件温和,操作简便易于进行的优点。更多还原

【Abstract】 Aim To synthesize novel physiologically-active and pharmaceutically-acceptable compounds. MethodsSchiff bases of amino-3-dihydrothiophenon-2(Ⅱ) were synthesized by reaction of substituted benzaldehyde with D L-homocysteine thiolactone hydrochloride(ADT·HCl) by means of preferable reaction conditions.Results Six of them are reported for the first time.Conclusion The structures of the compounds were confirmed by elemental analysis,~1H NMR and IR spectroscopy.The reported methods were of mild and available for performance.更多还原