【摘要】 目的探讨多囊卵巢综合征(PCOS)患者肾素血管紧张素与雄激素及胰岛素抵抗的相关性。方法选择PCOS患者和正常对照组妇女各40例,检测血浆肾素活性(PRA)、血管紧张素Ⅱ(AngⅡ)、胰岛素、血糖和性激素水平。结果①F-G评分、LH/FSH比值、T、PRA和AngⅡ浓度,空腹胰岛素(FINS)、胰岛素抵抗指数(Homa IR)、胰岛素分泌指数(Homaβ)显示,PCOS组>对照组(P<0.05);②PCOS组PRA与月经周期、AngⅡ、LH/FSH、T、FINS、Homa IR、Homaβ、β细胞功能评定指数(MBCI)呈正相关性(分别为r=0.40,0.44,0.37,0.35,0.50,0.42,0.48,0.38,P<0.05);AngⅡ与月经周期、LH/FSH比值、T呈正相关(分别r=0.34,0.32,0.42,P<0.05);AngⅡ与FSH呈负相关(r=-0.36,P<0.05)。结论①多囊卵巢综合征存在肾素-血管紧张素-雄激素级联亢进;②RAS亢进可能参与PCOS胰岛素抵抗和生育障碍的发生。更多还原

【Abstract】 Objective To investigate the correlation between renin-angiotensin system（RAS） and testosterone,and insulin resistance in women with polycystic ovary syndrome（PCOS）.Methods Plasma renin activity（PRA） and the concentrations of AngⅡ,serum FSH,LH,T,E₂,insulin and glucose were measured in 40 women with PCOS and in 40 controls.Results ① Ferriman-Gallwey score,LH/FSH,Serum T level, plasma PRA and concentration of AngⅡ were significantly higher in women with PCOS than those in healthy women （（P<0.05））.② Positive correlation was found significantly between PRA and menstrual cycles,AngⅡ,and LH/FSH,T,fasting insulin（FINS）,insulin resistance index（HomaIR）,Homa β,modified beta-cell function index（MBCI） in women with PCOS（r=0.40,0.44,0.37,0.35,0.50,0.42,0.48,0.38,P<0.05）.Plasma angiotensin Ⅱ correlated significantly with menstrual cycles,LH/FSH, and T（r=0.34,0.32,0.42,P<0.05）.There was significant negative correlation between AngⅡ and FSH（r=-0.36,P<0.05）.Conclusion There is elevation of cascade from rennin angiotensin system to androgen,which may take part in insulin resistance and anovulation in women with polycystic ovary syndrome.更多还原