【摘要】 目的:比较新型抗精神病药物奎硫平与传统抗精神病药物氟哌啶醇治疗谵妄的疗效与安全性。方法:将入组谵妄病人共56例随机分成奎硫平治疗组(n=30)和氟哌啶醇治疗组(n=26),采用简明精神病量表(BPRS)、临床总体印象量表(CGI)及副反应量表(TESS)进行评估,前瞻性观察治疗14d。结果:①奎硫平组和氟哌啶醇组治疗后显效率分别为83.33%与84.62%,两组显效率差异无显著性(P>0.05)。②两组临床总体印象量表严重度SI分值在治疗后均明显降低,较治疗前差异具有显著性(P<0.01),两组间差异无显著性(P>0.05)。③奎硫平组常见不良反应为头晕,氟哌啶醇组则以口干及锥体外系症状多见;不良反应总的发生率氟哌啶醇组明显高于奎硫平组,两组差异有显著性(P<0.01)。结论:奎硫平与氟哌啶醇治疗谵妄疗效相当,但奎硫平不良反应较小,可以替代传统抗精神病药物用于谵妄的治疗。更多还原

【Abstract】 Objective:To compare the efficacy and safety of atypical antipsychotic agent quetiapine with typical antipsychotic agent haloperidol in delirium.Methods:Fifty-six of patients with delirium were randomly divided into quetiapine treatment group(n = 30) and haloperidol treatment group(n = 26).They were prospectively observed and treated for 14 days,assessed with Brief Psychiatric Rating Scale(BPRS),Clinical Global Impression Scale(CGI) and Treatment Emergent Symptom Scale(TESS).Results:① The effective rate of quetiapine treatment group and haloperidol treatment group were 83.33 % and 84.62% respectively.The effective rate of two groups had no significant difference(P> 0.05).② CGI-SI scores of quetiapine treatment group and that of haloperidol treatment group were both reduced significantly after treatment(P<0.01).CGI-SI scores of two groups after treatment had no significant difference(P>0.05).③ Dizziness was a common side effect of quetiapine,dry mouth and extrapyramidal symptoms were more often incident in haloperidol group.The total incidence rates of side effect in haloperidol treatment group were higher than that in quetiapine treatment group,which had significant difference(P<0.01).Conclusion:Quetiapine and haloperi-dol have similar effects on delirium.However,quetiapine has fewer side effects.Quetiapine may be a useful alternative agent to classical antipsychotics in the treatment of delirium.更多还原