【摘要】 目的:探讨慢性前列腺炎(CP)的细菌学病因。方法:前列腺标本取自140例意外死于非前列腺疾病的器官捐献者,年龄20～35岁。取前列腺周围带组织,分成两块,一块做常规病理检查和抗IgA抗体组化染色,另一块用PCR方法检测细菌16SrRNA基因(16SrDNA)。结果:32.9%(46/140)的组织病理呈CP,其中轻度灶性间质炎42例,轻度灶性间质伴腺体周围炎3例,轻度灶性腺体周围炎1例。16SrDNA阳性率为19.3%(27/140)。其中前列腺炎标本阳性率为48.9%(22/46),非前列腺炎标本阳性率为5.3%(5/94),前列腺炎标本阳性率高于非前列腺炎标本(x2=36.910,P<0.01)。在CP标本中,16SrDNA阳性组IgA表达高于16SrDNA阴性组(Z=-3.85,P<0.001)。结论:细菌感染可能是引起CP的重要原因。更多还原

【Abstract】 Objective:To explore and discuss the role of bacteria in the etiology of chronic prostatitis. Methods:Specimens of prostate were obtained at autopsy from 140 organ donors (aged 20-35years) died of non-prostatic disease. Tissue from the peripheral zone of each prostate was divided into two pieces. Then one piece of tissue was taken for routine pathological examination and immunohistochemical studies by using anti-IgA antibody. The another piece was detected for PCR assay to detect bacteria 16S rRNA gene (16S rDNA). Results:Of 140 prostate specimens, 46 (32.9%) presented pathological changes of chronic prostatitis: focal mild periglanduar inflammation was found in 42 inflammation, focal mild periglanduar inflammation and periglanduar inflammation and in 3 focal mild periglanduar inflammation in one. 27 (19.3%) was positive for 16S rDNA: 48.9% (22/46) of the chronic prostatitis specimens, 5.3%(5/94) of the non- prostatitis specimens (P<0.01). Of 46 specimens with chronic prostatitis, significant expression of IgA was more often demonstrated in 16S rDNA positive group than that in 16S rDNA negative group (Z=-3.85, P<0.001). Conclusions:Bacteria may play an important role in histologically chronic inflammatory prostatitis.更多还原