【摘要】 目的:探讨人乳头瘤病毒16型E7抗原表位E749-57及其修饰肽是否能够在体诱导特异性细胞毒性T细胞杀伤效应,以及是否具有相应的治疗作用。方法:以HPV16E749-57及其修饰肽免疫荷瘤小鼠,研究小鼠肿瘤的生长特性和转移规律。结果:经修饰肽和原有表位HPV16E749-57免疫的荷瘤小鼠,瘤细胞的转移率显著降低,平均存活时间明显延长。结论:修饰肽具有特异性细胞毒性T细胞诱导活性,并且能够起到一定的治疗作用。更多还原

【Abstract】 Objective:To investigate the abilitiy of HPV16E749-57 and the peptide modified from E749-57 to induce the generation of specific cytotoxicity T lymphocyte in vivo, and its therapeutical effect. Methods: the mouse with tumor was immunized with HPV16E749-57 and the peptide modified from E749-57, and growth behavior and metastatic pattern of tumor were studied in mouse. Results:HPV16E749- 57 and the peptide modified from E749-57 had the effect of lowering the metastasis rate and extended the mean survival time. Conclusion:The peptide modified from HPV16E749-57 has the activity of inducing cytolytic t lymphocytes,and the therapeutical effect.更多还原