【摘要】 转化生长因子β(TGF-β)是与肺纤维化关系较为密切的细胞因子。Sm ad蛋白为TGF-β受体后下游的主要信号转导因子,其中Sm ad3是纤维化疾病的重要介导者,Sm ad7是TGF-β信号转导途径的主要抑制性蛋白,它们的异常表达可影响TGF-β活性,进而改变纤维化进程。调控Sm ad3,Sm ad7的表达可能为治疗纤维化疾病提供一种新手段。更多还原

【Abstract】 Transforming growth factor-β(TGF-β) plays a central role in pulmonary fibrosis.The Smads act the downstream of receptors for the transforming growth factor-β family of ligands,among which Smad3 functions as a mediator of fibrotic disorder,while Smad7 is a major inhibitory regular in TGF-β signaling pathway.The abnormal expression of Smad3 or Smad7 can affect the activity of TGF-β and accordingly change the process of fibrosis.The modulation of Smad3 or Smad7 expression may have tremendous clinical potential in therapeutic strategy for fibrotic diseases.更多还原