【摘要】 无义介导的mRNA降解(nonsense-m ed iated mRNA decay,NMD)能够选择性降解含有翻译提前终止密码子(prem ature translation term ination condon,PTC)的mRNA,从而防止对机体有害的截短蛋白(truncated pro-te ins)的产生,它是真核生物中广泛存在的一种高度保守的有效的监督机制。NMD与肿瘤发生发展过程中的基因突变有密切关系。更多还原

【Abstract】 In eukaryotic cells,nonsense-mediated mRNA decay(NMD) is an evolutionarily well-conserved and effective mRNA surveillance mechanism that can selectively degrade mRNAs with premature translation termination codons(PTC) and protect cells from the potentially deleterious effects of truncated proteins.NMD is intimately associated with gene mutation in the occurence and development of human cancer.更多还原