【摘要】 Ras,Raf基因突变及MAPK的过度激活与人类肿瘤的发生密切相关,而且由于ERK通路在细胞信号转导中的枢纽地位,其作为抗肿瘤的分子靶受到基础研究与药物开发工作者的广泛关注,为肿瘤治疗提供了可喜的前景。更多还原

【Abstract】 The mutation of Ras and Raf gene and the over-activation of MAPK are closely related with the occurrence of human cancers in recent years.Because of the pivotal status of ERK pathway in cell signal transduction,many basic scientific researchers and drug developers who regard ERK pathway as anti-cancer molecular targets pay more attention to it and present a promising future.更多还原