【摘要】 目的:观察利骨素对去卵巢大鼠骨矿盐丢失的预防作用。方法:健康4月龄SD雌性大鼠24只,随机分成4组,A组(正常对照);B组(假去卵巢);C组(去卵巢);D组(去卵巢+利骨素)。取左股骨测定骨矿盐含量。结果:去卵巢大鼠骨干重、骨干重/体重、骨灰重、骨灰重/体重、骨灰重占骨干重(%)等指标均明显降低,持续服用利骨素11周,可使实验组大鼠上述指标明显高于去卵巢组。提示:利骨素有良好的预防去卵巢引起的骨矿盐丢失作用。更多还原

【Abstract】 Objective:To investigate the effect of the LIGUSU on mineral content of ovariectomized rats.Methods: 24 female Spragul-Dawtey(SD) rats were randomly divided into 4 groups with 6 rats in each group : ①normal control group;②sham ovariectomy group;③ovariectomy(OVX) group;④OVX+LIGUSU group.The rats in the 4th group recieved LIGUSU from the next day after operation for 11 weeks,meanwhile the 3rd group were given equal volume of normal saline.All rats were killed by arterial blood letting under anesthesia at the end of the eleventh week.The bone dry mass,bone dry mass/body mass,bone ashes mass,bone ashes mass/body mass,bone ashes mass/bone dry mass(%)were observed Results: The bone dry mass,bone dry mass/body mass,bone ashes mass,bone ashes mass/body mass,bone ashes mass/bone dry mass(%) were significantly lower in the OVX group than in the normal control group and in the sham OVX group,but all these changes were markely increased in the 4th group as compared with OVX group.Conclusions:It suggests that LIGUSU opposes the bone mineral loss well in OVX rats.更多还原