【摘要】 博尔纳病病毒(Borna Disease Virus,BDV)是一种具有高度嗜神经性的病毒。近年,有大量研究证实该病毒感染与人神经精神疾病的发生有关。但其确切机制仍未明了。一些研究认为BDV感染对中枢神经系统神经元可塑性的影响可能是其致病的重要基础。近年许多学者通过对沙鼠、小鼠、大鼠及转基因鼠等各种BDV感染模型的研究,进一步揭示了BDV感染对神经元可塑性影响的分子机制。结果发现BDV感染主要通过对星形胶质细胞功能的影响、干预HMGB 1蛋白以及神经营养因子信号转导等途径干预神经元的可塑性,影响脑内神经元的功能及其存活和发育,从而引起脑功能损害,导致宿主精神、行为异常。今后随着新的BDV转基因模型的成功建立将进一步揭示BDV感染对神经元可塑性影响的分子机制,给临床预防和治疗博尔纳病提供理论基础。更多还原

【Abstract】 Borna disease virus(BDV) is highly neuronotropic.Recently,more and more investigations indicated that BDV infection was close related to human neuropsychic disorders.However,the mechanism underlying the disorders was unclear to date.Some investigators thought neuronal plasticity changes by BDV infection in the central nervous system may be it’s cardinal basis.Many researchers have studied the molecular mechanisms,which might lead to disturbances in neuronal plasticity by BDV infection,through infection-based animal modes such as gerbils modes,rats modes,mice modes and transgenic mice modes.The results showed that neuronal plasticity was interfered by BDV infection through interference with trophic support from astrocytes to neurons,interference with amphoterin signaling and interference with neurotrophin signaling.The disturbances in neuronal plasticity would result in cerebral disorders and cause behavior alterations and psychic alterations of host.In the following years,the ability to manipulate the BDV genome may help uncover unrecognized aspects of the basic mechanisms operating in the regulation of neuronal plasticity of interference with neuronal physiology caused by BDV,give academic foundation for clinical prevention and therapy of BD.更多还原