【摘要】 合成了4个新的有机锡联苯乙酸酯｛[(n-C4H9)2Sn(O2CCH2C6H4C6H5-4)]2O｝2(1)和R3SnO2CCH2C6H4C6H5-4(R=C6H5,2;c-C6H11,3;C6H5C(CH3)2CH2,4),利用元素分析、IR、1H和13CNMR表征了其结构。通过X-射线单晶衍射测定了1和4的晶体结构。化合物1和化合物4均属三斜晶系,空间群P1。化合物1为具有Sn2O2四元环的中心对称二聚体结构,4为畸变的四面体结构。生物活性测试结果表明,化合物1和4对3种人癌细胞HeLa、CoLo205和MCF-7具有较好的体外抑制活性。更多还原

【Abstract】 Four organotin 4-biphenylacetates,{[(n-C4H9)2Sn(O2CCH2C6H4C6H5-4)]2O}2(1)and R3SnO2CCH2C6H4C6H5-4(R=C6H5,2;c-C6H11,3;C6H5C(CH3)2CH2,4),have been prepared and characterized by elemental analysis,IR,1H and 13C NMR spectroscopes.The crystal structures of 1 and 4 have been determined.The crystal of 1 belongs to triclinic space group P1 with a=1.281(2)nm,b=1.379(2)nm,c=1.447(2)nm,α=76.15(2)°,β=65.47(2)°,γ=69.78(2)°,Z=1,V=2.168(4)nm3,R1=0.036 6,wR2=0.115 2.The crystal of 4 belongs to triclinic space group P1 with a=1.052(1)nm,b=1.128(1)nm,c=1.847(2)nm,α=75.45(1)°,β=74.94(1)°,γ=64.19(1)°,Z=2,V=1.880(3)nm3,R1=0.029 5,wR2=0.072 0.The compound 1 has a centrosymmetric dimmer structure with a four-membered cyclic Sn2O2 unit,and the compound 4 possesses a distorted tetrahedral structure.Bioassay results have shown that the compounds display good in vitro antitumor activity against three human tumour cell lines,HeLa,CoLo205 and MCF-7.CCDC:250637,1;608675,4.更多还原