【摘要】 目的观察吸入1%的七氟醚或等效浓度的异氟醚对罗库溴铵临床药效的影响。方法选择无神经肌肉疾患,在全麻下行择期手术的病人45例,随机分成异丙酚—N₂O组（A组）,七氯醚—N₂O组（B组）和异氟醚—N₂O（C组）。采用TOF刺激方式监测拇内收肌的收缩反应。罗库溴铵的诱导剂量为0．6mg·kg^-1。当T₁恢复至对照值的25%时开始静滴罗库溴铵,记录罗库溴铵的起效时间,临床作用时间(T₂₅),维持T₁在1%～10%所需罗库溴铵的输注速度及恢复指数(T₂₅～T₇₅)。结果A、B和C组的起效时间分别是89．1±17．2秒、84．5±15．6秒和87．7±16．0秒（P＞0．05）；作用时间分别是34．2±12．4 min、45．6±14．6 min和43．4±13．1 min（P＜0．05）,维持90%～99%颤搐抑制所需罗库溴铵的输注速度分别为6．71±1．83μg．kg^-1·min^-1、4．87±1．43μg·kg^-1·min^-1和5．43±1．63μg·kg^-1min^-1（P＜0．01）；恢复指数分别为10．8±4．2 min、14．6±4．8 min和16．2±5．3 min。结论1%的七氟醚及等效浓度的异氟醚均可增强罗库溴铵的临床药效,但二者之间的增强效应无显著差异。更多还原

【Abstract】 Objective:To observe the effects of 1% sevoflurane and equivalent isoflurane on pharmacodynamics of rocu- ronium.Methods:Forty-five ASAⅠ-Ⅱpatients without any neuromuscular disease undergoing elective surgery under gen- eral anesthesia were randomly divided into three groups of 15 patients each.In group A,the anesthesia was maintained by continuous propofol and inhaling 67% N₂O,in group B by inhaling 1.0% sevoflurane-67% N₂O and in group C by 0.7% isoflurane-67% N₂O.Thumb adductorius contractile response was monitored with TOF stimulation when T1 recovering 25% of control value,0.04% rocuronium was intravenously infused.Results:Onset times of rocuronium in three groups were 89.1±17.2s,84.5±15.6 s and 87.7±16.0 s （P＞0.05）.Clinical duration in group Band C was longer than that in group A （45.6±14.6 min,43.4±13.1 min and 34.2±12.4 min P＜0.01）.The infusion rates of rocuronium to main- tain 90%～99% blockade in three groups were 6.71±1.83μg·kg^-1·min^-1,4.87±1.43μg·kg^-1·min^-1 and 5.43±1.63μg·kg^-1·min^-1 （P＜0.01）,and recovery, index in three groups were 10.8±4. 2 min,14.6±4.8 min and 16.2±5.3 min （P＜0.01）.Conclusion:It is suggested that 1.0% sevoflurane and equipotant isoflurane can potentiate the muscular relaxation action of rocuronium.更多还原