【摘要】 目的为开发新的抗癌药物提供一定的理论研究依据。方法在Tris-NaCl（pH=7．2）缓冲溶液中,应用电化学实验、电子吸收光谱分析等技术研究了Cu（phen）₂²⁺（phen=1,10-邻菲咯啉）与6-羟基嘌呤（6-HX）及DNA间的相互作用。结果Cu（phen）₂²⁺与6-HX发生了较弱的相互作用,其作用产物与DNA间也存在较弱的相互作用。结论在此作用体系中Cu（phen）₂⁺²、6-HX、Cu（phen）₂²⁺·6-HX复合物间可能存在如下平衡：Cu （phen）₂²⁺+6-HX（?）Cu（phen）₂（2+）·6-HX复合物,少量DNA的存在可以加速Cu（phen）₂²⁺·6-HX复合物的解离。更多还原

【Abstract】 Objective:To provide the tbeoretical basis for developing new anticancer drug.Methods:The interaction of Cu（phen）₂²⁺（phen=1,10-phenanthroline）with 6-hypoxanthine（6-HX） and DNA in Tris-NaC1 buffer solution （pH=7. 2）was investigated by electrochemistry,electron absorption spectroscopy technique.Results:Experimental results showed a weak interaction between Cu（phen）₂²⁺ complex and 6-HX,and the interaction of theit binding product with calf thymus DNA was also weak.Conclusion:The results indicate that there is an obvious interaction equilibrium among Cu（phen）₂²⁺ complex,6-HX and DNA as follows:Cu（phen）₂²⁺ + 6-HX（?）Cu（phen）₂²⁺·6-HX.Wben DNA is added to the solu- tion,it makes the interaction equilibrium move leftwards.更多还原