【摘要】 目的采用HPMC和Carbopol制备胃漂浮胶囊。方法以阿司匹林为模型药物,以不同黏度和不同用量的HPMC和Carbopol为主要辅料制成胃内漂浮型胶囊,采用桨法测定了Asp漂浮胶囊的释放度。结果当HPMCK4M和HPMCK15M的最佳配比为3∶1,阿司匹林胃漂浮胶囊在0~10 h内体外释药符合表观零级动力学过程,体外释放速度常数Kr=10.3%.h-1。经Peppas方程拟合后得出释放参数n=0.6173。从0.45<n<0.89表明,体外释药特征属于骨架溶蚀与药物扩散协同作用。结论HPMC用量、粘度为影响阿司匹林胃漂浮胶囊释放速率的主要因素。更多还原

【Abstract】 Objective: To develop a gastric floating sustained release capsule by the use of HPMC and Carbopol as matrix material.Methods: Aspirin was as a model drug,the gastric floating capsule containing different viscosity HPMC and various dosage Carbopol as main excipients,and paddle method was adopted to determine Asp-HBS release rates in vitro.Results: When the ratio between HPMCK4M and HPMCK15M（3∶1） was the best proportion,aspirin gastric floating in vitro release accorded with zero-order kinetics,and the constant of in vitro release was Kr=10.3%·h^-1.Via Peppas equation simulation,the drug release character was marix erode and drug diffuse.Conclusion: The amount and viscosity of HPMC significantly influence aspirin release from the gastric floating capsule.更多还原