【摘要】 在间歇高压釜中用薄荷醇、异丁烯和CO在PdCl2(PPh3)2、PPh3和P-CH3C6H4SO3H共同作用羰基合成了异戊酸薄荷醇酯(Validol,伐力多)。研究了反应温度、压力,溶剂,催化剂浓度以及薄荷醇和异丁烯浓度对反应的薄荷醇转化率、Validol选择性和收率的影响。在最佳反应条件下进行10h以上反应时,薄荷醇的转化率可达95.96%,Validol的选择性大于96.80%,异丁烯转化率大于96.60%。更多还原

【Abstract】 The Carbonization of isobutene and menthol for Validol （menthyl valerate） synthesis was carried out in the catalytic system containing PdCl₂（PPh₃）₂,PPh₃ and p-CH₃C₆H₄SO₃H in an autoclave.The effects of reaction conditions,suchas temperature,pressure,solvents and the concentrations of catalysts,menthol and isobutene,on menthol conversion,Validol selectivity and yield were examined.Under the optimum reaction conditions,the conversion of menthol was up to 95.96%,the selectivity to Validol was more than 96.80%,and the conversion of isobutene was more than 96.60% in 10 hours.更多还原